Millions of Britons are thought to take aspirin every day in the hope of warding off a heart attack, because of its blood thinning properties.
Men below 60 were a third more likely to have hearing problems if they regularly took aspirin, the study found. However there was no greater risk in those over 60, the findings suggest. For paracetamol users the risks were even higher.
For those under 50 the chance of hearing loss was effectively doubled, while those in their 50s were 38 per cent more likely to suffer problems. The risk, however, continued to fall as volunteers got older.
Those aged 60 and over were 16 per cent more likely to have difficulty hearing than those of a similar age who did not regularly take the drug.
For the class of Non-steroidal anti-inflammatory drugs (NSAIDs), which include Ibuprofen, they were found to increase the risk by 61 per cent for the under 50s, 32 per cent for those in their 50s and 16 per cent for those aged 60 and over.
The findings, by researchers from Harvard University Brigham and Women's Hospital, Vanderbilt University and the Massachusetts Eye and Ear Infirmary, Boston are published in the American Journal of Medicine.