Leeches for infections, mercury for syphilis and honey smeared on wounds

The development of antibiotics and other antimicrobial therapies is arguably the greatest achievement of modern medicine. But before their existence, doctors used everything from knives to leeches and even honey.
And now, researchers say the rise of the superbugs mean we may need to revisit the old techniques.

Overuse and misuse of antimicrobial therapy predictably leads to resistance in microorganisms, and Antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus species(VRE) and carbapenem-resistant Enterobacteriaceae (CRE) have emerged. Certain CRE species are resistant to multiple antibiotics, and have been deemed 'superbugs' in the news.
Alternative therapies have been used to treat infections since antiquity, but none are as reliably safe and effective as modern antimicrobial therapy.
Unfortunately, due to increasing resistance and lack of development of new agents, the possibility of a return to the pre-antimicrobial era may become a reality.
So how were infections treated before antimicrobials were developed in the early 20th century?

Source  - Daily Mail